Suchergebnisse

We propose a periodic structure that behaves as a fluid fluid composite for sound waves, where the building blocks are clusters of rigid scatterers. Such building-blocks are penetrable for acoustic waves, and their properties can be tuned by selecting the filling fraction. The equivalence with a fluid fluid system of such a doubly periodic composite is tested analytical and experimentally. Because of the fluid-like character of the scatterers, sound structure interaction is negligible, and the propagation can be described by scalar models, analogous to those used in electromagnetics. As an example, the case of focusing of evanescent waves and the guided propagation of acoustic waves along an array of penetrable elements is discussed in detail. The proposed structure may be a real alternative to design a low contrast and acoustically penetrable medium where new properties as those shown in this work could be experimentally realized. ; We acknowledge financial support by Spanish Ministerio de Economia y Competitividad and European Union FEDER through project FIS2011-29731-C02-01 and -02. VRG is grateful for the financial support of the post-doctoral grant from the "Pays de la Loire". ACR is grateful for the support of the Programa de Ayudas e Iniciativas de Investigacin (PAID) of the UPV. ; Cebrecos Ruiz, A.; Romero García, V.; Picó Vila, R.; Sánchez Morcillo, VJ.; Botey, M.; Herrero, R.; Cheng, YC. (2015). Acoustically penetrable sonic crystals based on fluid-like scatterers. Journal of Physics D-Applied Physics. 48(2):25501-25510. https://doi.org/10.1088/0022-3727/48/2/025501 ; S ; 25501 ; 25510 ; 48 ; 2

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10−8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality. ; This research has been conducted using the UK Biobank Resource. The Fenland Study is supported by the UK Medical Research Council (MRC) (MC_UU_12015/1; MC_UU_12015/2; MC_UU_12015/3). EPIC-Norfolk is supported by the MRC (G401527, G1000143) and Cancer Research UK (A8257). The HCS is gratefully supported by the University of Newcastle (Australia) and the Fairfax Family Foundation. Sydney MAS is supported by the Australian National Health and Medical Research Council (NHMRC), grants ID568969, ID350833 and ID109308. Sydney MAS DNA was extracted by Genetic Repositories Australia, funded by NHMRC Enabling Grant 401184. The GEFOS Study, used as controls for the US and Jamaican athletes, was supported in part by NIH grants U01 HG004436 and P30 DK072488, and the Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs. The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk). TwinsUK was funded by the Wellcome Trust (WT), MRC, and European Union. The study also receives support from the National Institute for Health Research (NIHR) BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. SNP Genotyping was performed by The WT Sanger Institute and National Eye Institute via NIH/CIDR. M.McC is a WT Senior Investigator and receives support from WT 090532 and 098381. TW is the recipient of a studentship from MedImmune. Research by A. Lucia is supported by Fondo de Investigaciones Sanitarias and Fondos Feder (grant # PI15/0558). EM-M. was a recipient of a Grant-in-Aid for JSPS Fellow from the Japan Society for the Promotion of Science. This work was supported in part by grants from the Grant-in-Aid for Scientific Research (B) (15H03081 to NF) of the Japanese Ministry of Education, Culture, Sports, Science and Technology and by a grant-in-aid for scientific research (to M. Miyachi) from the Japanese Ministry of Health, Labor, and Welfare. This work was further supported by NIH grants R01 AR41398 and U24 AG051129.